What is the role of reticulocyte hemoglobin content (CHr) testing in the diagnosis of iron deficiency anemia?

Updated: Sep 07, 2019
  • Author: James L Harper, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Mateos Gonzales et al assessed the diagnostic efficiency of commonly used hematologic and biochemical markers, as well as the reticulocyte hemoglobin content (CHr) in the diagnosis of iron deficiency in children, with or without anemia. [15] The investigators identified CHr and iron serum as the only parameters that were independently associated with iron deficiency (P< .05), and CHr was the strongest predictor of iron deficiency and iron deficiency anemia.

Mateos Gonzalez et al concluded that measurement of CHr may be a reliable method to assess deficiencies in tissue iron supply and, in combination with a CBC, may be an alternative to the traditional biochemical panel for the diagnosis of iron deficiency in children. [15]

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