What is iron-refractory iron deficiency anemia (IRIDA)?

Updated: Aug 04, 2019
  • Author: James L Harper, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

Iron-refractory iron deficiency anemia (IRIDA) is a hereditary disorder marked by with iron deficiency anemia that is typically unresponsive to oral iron supplementation and may be only partially responsive to parenteral iron therapy. IRIDA results from variants in the TMPRSS6 gene that lead to uninhibited production of hepcidin. IRIDA is characterized by microcytic, hypochromic anemia and serum hepcidin values that are inappropriately high for body iron levels.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!