What are the ASH recommendations for second and third-line therapy for immune thrombocytopenic purpura (ITP) during pregnancy?

Updated: Jun 28, 2019
  • Author: Craig M Kessler, MD, MACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Second-line therapy for refractory ITP is with combined corticosteroids and IVIg or, in the second trimester, splenectomy.  For third-line therapy, anti-D immunoglobulin and azathioprine are relatively contraindicated. Agents that are not recommended, but whose use in pregnancy has been described, include the following:

  • Cyclosporine
  • Dapsone
  • Thrombopoietin receptor agonists
  • Campath-1H
  • Rituximab

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