What are the ASH recommendations for first-line treatment of immune thrombocytopenic purpura (ITP) in adults?

Updated: Apr 22, 2018
  • Author: Craig M Kessler, MD, MACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

ASH suggests that newly diagnosed patients receive treatment if their platelet count is < 30 × 109/L. Suggestions for first-line treatment include the following:

  • Longer courses of corticosteroids are preferred over shorter courses of corticosteroids or IVIg
  • IVIg may be used with corticosteroids when a more rapid increase in platelet count is required
  • Either IVIg or anti-D (in appropriate patients) may be used if corticosteroids are contraindicated
  • If used, IVIg should be administered in a single dose of 1 g/kg; this dose may be repeated if necessary

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