What are the International Consensus Report recommendations for the assessment of quality of life outcomes in adults with immune thrombocytopenia (ITP)?

Updated: Jan 11, 2020
  • Author: Craig M Kessler, MD, MACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Assessment and management of health-related quality of life outcomes

The 10-scale ITP-patient assessment questionnaire (ITP-PAQ) is an ITP-specific questionnaire that can be used to measure HRQoL, with estimated minimally important differences (MIDs) aiding interpretation. Additional measures of patient-reported outcomes (PROs) that have been studied in adult patients with ITP include the following:

  • 36-item Short Form Health Survey (SF-36)
  • EuroQol tool (EQ-5D)
  • Hamilton anxiety and expression rating scales
  • Motivation and energy inventory-short form (MEI-SF)
  • Fatigue subscale of the functional assessment of chronic illness therapy (FACIT-Fatigue)
  • Functional assessment of cancer therapy–thrombocytopenia (FACT-Th6)

Impaired HRQoL is multifactorial and includes (but is not limited to) issues around actual bleeding, fear of bleeding, reduced energy, depression, treatment side effects, and additive influences of underlying or comorbid diseases. Patients who respond to treatment have improved HRQoL, with those who respond to TPO-RA improving more than those who respond to other therapies; in particular, romiplostim may improve fatigue.


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