What are the ASH recommendations for the initial treatment of immune thrombocytopenic purpura (ITP) in children?

Updated: Apr 22, 2018
  • Author: Craig M Kessler, MD, MACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

ASH recommendations include the following:

  • First-line treatment for pediatric patients requiring treatment can be a single dose of IVIg (0.8 to 1 g/kg) or a short course of corticosteroids
  • IVIg can be used if a more rapid increase in the platelet count is desired
  • Anti-D therapy is not advised in children whose hemoglobin concentration is decreased because of bleeding, or with evidence of autoimmune hemolysis (grade 1C)

ASH suggests that a single dose of anti-D can be used as first-line treatment in Rh-positive, nonsplenectomized children requiring treatment (grade 2B).


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