How is drug-induced thrombocytopenia diagnosed?

Updated: Apr 22, 2018
  • Author: Craig M Kessler, MD, MACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

For a diagnosis of drug-induced thrombocytopenia to be made with confidence, all of the following criteria must be met:

  • The development of the low platelet count should exhibit a strict temporal relationship with the initiation of the medication
  • The platelet count should recover when the offending medication is discontinued
  • The likelihood of drug-induced thrombocytopenia should be greater than any other plausible cause
  • Ideally, in vitro evidence of drug-dependent antibody formation should exist

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