Which factors increase the risk of developing chronic immune thrombocytopenic purpura (ITP)?

Updated: Apr 22, 2018
  • Author: Craig M Kessler, MD, MACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

A systematic review and meta-analysis identified the following factors associated with higher risk of ITP in children becoming chronic [32] :

  • Female gender (odds ratio [OR] 1.17)

  • Age ≥11 years at presentation (OR 2.47)

  • No preceding infection or vaccination (OR 3.08)

  • Insidious onset (OR 11.27)

  • Platelet count ≥20 × 109/L at presentation OR 2.15)

  • Presence of antinuclear antibodies(OR 2.87)

  • Treatment with methylprednisolone plus intravenous immunoglobulin (OR 2.67)


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