Which factors increase the risk of developing chronic immune thrombocytopenia (ITP)?

Updated: Jan 11, 2020
  • Author: Craig M Kessler, MD, MACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

A systematic review and meta-analysis identified the following factors associated with higher risk of ITP in children becoming chronic [33] :

  • Female gender (odds ratio [OR] 1.17)
  • Age ≥11 years at presentation (OR 2.47)
  • No preceding infection or vaccination (OR 3.08)
  • Insidious onset (OR 11.27)
  • Platelet count ≥20 × 10 9/L at presentation (OR 2.15)
  • Presence of antinuclear antibodies (OR 2.87)
  • Treatment with methylprednisolone plus intravenous immunoglobulin (OR 2.67)

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