What is the primary cause of morbidity and mortality in immune thrombocytopenia (ITP)?

Updated: Jan 11, 2020
  • Author: Craig M Kessler, MD, MACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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The primary cause of long-term morbidity and mortality in patients with immune thrombocytopenia (ITP) is hemorrhage. [28] Spontaneous or accidental trauma–induced intracranial hemorrhage is the most frequent cause of death in association with ITP. Most cases of intracranial hemorrhage occur in patients whose platelet counts are less than 10 × 109/L (< 10 × 103/µL). [1] This situation occurs in 0.5-1% of cases in children, and half of those are fatal. [2] In one study, 17% of children experienced a major hemorrhage. [29] The estimated frequency of intracranial hemorrhage in adults with ITP is 1.5%. [30]

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