Which platelet complex is most commonly involved in the pathogenesis of immune thrombocytopenic purpura (ITP)?

Updated: Apr 22, 2018
  • Author: Craig M Kessler, MD, MACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

In persons with chronic ITP, approximately 75% of autoantibodies are directed against platelet GPIIb/IIIa or GPIb/IX GP complexes. Presumably, the remaining 25% are directed against other membrane epitopes, including GPV, GPIa/IIa, or GPIV


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