Which medications in the drug class SYK Inhibitors are used in the treatment of Immune Thrombocytopenic Purpura (ITP)?

Updated: Jun 28, 2019
  • Author: Craig M Kessler, MD, MACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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SYK Inhibitors

Fostamatinib, is a first-in-class spleen tyrosine kinase (SYK) inhibitor indicated for chronic IPT in adults.

Fostamatinib (Tavalisse)

Fostamatinib is a spleen tyrosine kinase (SYK) inhibitor. The major active metabolite of fostamatinib (ie, R406) inhibits signal transduction of Fc-activating receptors and B-cell receptor, thereby reducing antibody-mediated destruction of platelets. It is indicated for thrombocytopenia in patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment.

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