Which medications in the drug class Antineoplastics, Alkylating are used in the treatment of Hodgkin Lymphoma?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Antineoplastics, Alkylating

Antineoplastic agents interfere with cell reproduction. Some agents are specific to phases of the cell cycle, whereas others (eg, alkylating agents, anthracyclines, cisplatin) are not. Cellular apoptosis (ie, programmed cell death) is another potential mechanism of many antineoplastic agents.

Alkylating antineoplastic agents elicit their effects through the formation of covalent bonds with DNA, which disturbs protein synthesis and cellular division. They are able to form bonds with DNA of all cells, especially those which reproduce rapidly. Because of their nonspecific action on cells, toxicities to normal cells are an issue.

Mechlorethamine (Mustargen)

Mechloroethamine is a component of the MOPP (mechlorethamine, vincristine, procarbazine, prednisone) regimen. It exerts cytotoxic effect by inhibiting rapid proliferation of cancer cells.


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