Which medications in the drug class Antineoplastics, Vinca Alkaloid are used in the treatment of Hodgkin Lymphoma?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Antineoplastics, Vinca Alkaloid

The vinca alkaloid agents are naturally occurring or semisynthetic nitrogenous bases that elicit their cytotoxic effects through tubulin-binding properties and disruption of microtubule function, which lead to metaphase arrest.

Vinblastine (Velban)

Vinblastine is a vinca alkaloid that inhibits mitosis because of interactions with tubulin.

Dacarbazine (DTIC-Dome)

Dacarbazine is an alkylating agent that inhibits DNA, RNA, and protein synthesis. It inhibits cell replication in all phases of the cell cycle.

Vincristine (Vincasar PFS, Oncovin)

Vincristine is a vinca alkaloid with a mechanism of action similar to that of vinblastine. It is presumed to stop the metaphase stage therefore preventing microtubule formation in the mitotic spindle.


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