Which medications in the drug class Antineoplastics, Podophyllotoxin Derivatives are used in the treatment of Hodgkin Lymphoma?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Antineoplastics, Podophyllotoxin Derivatives

Podophyllotoxin derivative antineoplastic agents have cytotoxic effects on cell growth.

Etoposide (Toposar)

Etoposide is an epipodophyllotoxin that induces DNA strand breaks by disrupting topoisomerase II activity. This causes cell proliferation to arrest in the late S or early G2 portion of the cell cycle.

Procarbazine (Matulane)

Procarbazine is an alkylating agent with a mechanism of action similar to that of dacarbazine: inhibition of DNA, RNA, and protein synthesis. It inhibits cell replication in all phases of the cell cycle. It is part of COPP, BEACOPP and MOPP regimens.


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