Which medications in the drug class Antineoplastics, Alkylating, DMARDs, Immunomodulators are used in the treatment of Hodgkin Lymphoma?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Antineoplastics, Alkylating, DMARDs, Immunomodulators

Cyclophosphamide is a synthetic agent similar to nitrogen mustard. This agent requires activation in the liver to form its active intermediaries, which in turn modify and cross-link DNA, thereby inhibiting DNA, RNA, and protein synthesis. Eventually, apoptosis occurs.

Cyclophosphamide (Cytoxan)

Cyclophosphamide is an alkylating agent that is chemically related to nitrogen mustards. The mechanism of action of its active metabolites may involve cross-linking of DNA, which may interfere with growth of normal and neoplastic cells.


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