Which medications in the drug class Antineoplastics, Anthracyclines are used in the treatment of Hodgkin Lymphoma?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Antineoplastics, Anthracyclines

Anthracycline antineoplastic agents elicit their cytotoxic effects through nucleotide base intercalation and cell membrane lipid-binding. Intercalation inhibits nucleotide replication and action of DNA and RNA polymerases.

Doxorubicin (Adriamycin)

An anthracycline that functions as a DNA intercalator, doxorubicin inhibits topoisomerase II and produces free radicals, which may destroy DNA. The combination of these 2 events can inhibit the growth of neoplastic cells. Doxorubicin is administered intravenously and distributes widely into bodily tissues, including the heart, kidneys, lungs, liver, and spleen. It does not cross the blood-brain barrier and is excreted primarily in bile.


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