What are NCCN recommendations for the treatment of advanced Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The NCCN supports the following treatments for stage III-IV, (non-bulky) cHL [4] :

  • ABVD for six cycles or

  • In patients with an IPS < 3, Stanford V regimen for three cycles (12 weeks) or

  • In patients with an IPS ≥4, escalated BEACOPP regimen for six cycles

  • For stage III-IV (bulky) cHL, the NCCN recommendations are the same as above, with the addition of ISRT to original sites of bulky disease

The ESMO guidelines recommend the following [5] :

  • ABVD for six to eight cycles, followed by localized radiotherapy of residual lymphoma larger than 1.5 cm

  • Escalated BEACOPP for six cycles, followed by localized radiotherapy of residual lymphoma larger than 2.5 cm


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