How is the International Prognostic Score (IPS) for Hodgkin lymphoma (Hodgkin disease) calculated?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Patients with advanced disease are further risk stratified using the International Prognostic Score (IPS), which includes the following risk factors (for scoring, each factor receives 1 point) [31] :

  • Albumin < 4 g/dL
  • Hemoglobin < 0.5 g/dL
  • Male
  • Age ≥45 y
  • Stage IV disease
  • Leukocytosis: white blood cell count (WBC) >15,000/μL
  • Lymphopenia: Lymphocyte count < 8% of WBC and/or absolute lymphocyte count < 600 cells/μL

Based on the IPS score, patients with advanced disease can be categorized as follows [120] :

  • Good risk (IPS 0-1)
  • Fair risk (IPS 2-3)
  • Poor risk (IPS 4-7)

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