What is required for diagnosis of Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Guidelines contributor: Priyank P Patel, MD  Hematology/Oncology Fellow, Roswell Park Cancer Institute, University at Buffalo

Diagnosis

Updated guidelines on the management of Hodgkin lymphoma have been issued by the National Comprehensive Cancer Network (NCCN) [4] and the European Society for Medical Oncology (ESMO). [5] The NCCN and ESMO guidelines have very similar recommendations for the diagnostic evaluation. [4, 5] Histological evaluation is required for diagnosis according to the World Health Organization (WHO) classification of either nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) or one of four classic Hodgkin lymphoma (CHL) subtypes, as follows:

  • Nodular sclerosis CHL (NSCHL)
  • Mixed cellularity CHL (MCCHL)
  • Lymphocyte-depleted CHL (LDCHL)
  • Lymphocyte-rich CHL (LRCHL)

The presence of Hodgkin and Reed-Sternberg (HRS) cells is disease defining for CHL. Detection of lymphocyte-predominant (LP) cells is required for the diagnosis of NLPHL


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