What is the prevalence of infertility following treatment for Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The degree of infertility varies widely with the regimen used. MOPP chemotherapy causes permanent infertility in at least 80% of males and approximately 50% of females. [104] The escalated BEACOPP regimen results in infertility in nearly 100% of patients treated. [105] The ABVD and Stanford V regimens pose a lower risk of permanent sterility than regimens that contain an alkylating agent (eg, MOPP chemotherapy). [106]

The EORTC Lymphoma Group reported an 82% rate of recovery of fertility in male patients who were treated without alkylating agents. [107] Given the overall excellent prognosis of Hodgkin lymphoma and the early age of onset, it is important to keep fertility preservation in mind when designing treatment plans for these patients. Options include sperm banking for men and various pharmacologic treatments for women including gonadotropin-releasing hormone agonists, ovarian stimulation, and egg preservation.


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