What are the risk factors for cardiac complication of Hodgkin lymphoma (Hodgkin disease) therapy?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Mantle radiotherapy increases the risk the risk of coronary artery disease, chronic pericarditis, pancarditis, valvular heart disease, and defects in the conduction system. [100, 101] Patients with history of mediastinal radiation have a 3-fold increase in their risk of cardiac death.

A study of patients who had previously undergone mediastinal irradiation for Hodgkin lymphoma but who had no clinical evidence of heart disease demonstrated a significant incidence of silent coronary artery obstruction and previous ventricular damage. [102] Based on these results, it is reasonable to initiate functional screening 5 years after radiation therapy in patients with Hodgkin lymphoma.

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