What is the role of nivolumab in the treatment of Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In May 2016, the FDA approved the monoclonal antibody nivolumab for the treatment of classic Hodgkin lymphoma (cHL) that has relapsed or progressed after autologous hematopoietic stem cell transplantation (HSCT) and posttransplantation brentuximab vedotin. Approval was based on a combination of the phase 2 CheckMate 205 and phase 1 CheckMate 039 trials with an efficacy analysis conducted on data from 95 patients. Treatment with nivolumab showed an objective response rate (ORR) of 65% (CI 95%: 55-75; 62/95), a complete response rate (CRR) of 7% (CI 95%: 3-15; 7/95), and a partial response rate (PRR) of 58% (CI 95%: 47-68; 55/95). Among responders, the median duration of response was 8.7 months (CI 95%: 6.8-NE; range 0.0+, 23.1+). [97, 98]


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