What is the role of PET scanning in the treatment of advanced Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The role of interim PET-CT scans in the treatment of advanced Hodgkin lymphoma has become more established. A phase III trial showed that if interim PET-CT is negative after two cycles of ABVD, bleomycin can be stopped (ie, de-escalation to AVD) without compromising efficacy. [45] Notably, in the same trial, patients with a positive PET-CT went on to receive BEACOPP, but there was no randomized comparison of BEACOPP versus ABVD in the PET-positive patients. The 2018 NCCN guidelines support this approach, [4] which avoids the pulmonary toxicity associated with bleomycin.


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