What is the role of radiation for treatment of advanced Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Beyond chemotherapy, there is even more controversy regarding the role of radiation in advanced Hodgkin lymphoma. The majority of data to date suggest that radiation improves progression-free survival but without improving overall survival. [83, 84] When administered after ABVD or BEACOPP, radiation probably adds little benefit to the majority of patients. [17, 85] One exception may be those patients with bulky mediastinal disease—which is known to be a poor prognostic marker—whose outcomes may be improved with radiation. [86] It must be noted that if the Stanford V regimen is used, then radiation is an integral part of the regimen and must be given.


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