What is the role of the BEACOPP regimen in the treatment of advanced Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

An alternative regimen, escalated BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone), is recommended by the NCCN for patients with a poor prognosis, as indicated by an International Prognostic Score (IPS) of 4 or higher. [57] Four cycles of escalated BEACOPP are given, with slow responders receiving four additional cycles. [4]

Escalated BEACOPP has CR rates of up to 95% in some trials, [79] but whether this is superior to ABVD therapy in an era with effective salvage is not known. [58, 59] However, adjustments in the delivery of BEACOPP including a reduced number of cycles has proven to be equally effective as the original schedule but with less toxicity. [80]  Again, these modifications have not been compared to ABVD.


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