What is the role of the BEACOPP regimen in the treatment of advanced Hodgkin lymphoma (Hodgkin disease)?

Updated: Aug 03, 2020
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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An alternative regimen, escalated BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone), is recommended by the NCCN for patients with a poor prognosis, as indicated by an International Prognostic Score (IPS) of 4 or higher. [56] Four cycles of escalated BEACOPP are given, with slow responders receiving four additional cycles. [4]

Escalated BEACOPP has CR rates of up to 95% in some trials, [78] but whether this is superior to ABVD therapy in an era with effective salvage is not known. [57, 58] However, adjustments in the delivery of BEACOPP including a reduced number of cycles has proven to be equally effective as the original schedule but with less toxicity. [79]  Again, these modifications have not been compared to ABVD.

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