What is advanced Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Patients are considered to have advanced Hodgkin lymphoma if they demonstrate stage III or IV disease. Chemotherapy is the mainstay of therapy, with radiation reserved for initial bulky sites or residual activity on positron emission tomography (PET) scans, but even in these situations, the role of radiation remains an area of debate. When patients present with advanced disease, they are staged as outlined in Staging, and their prognosis is determined by calculation of the International Prognostic System (IPS) (see Prognosis).

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