What is early-stage, unfavorable Hodgkin lymphoma (Hodgkin disease)?

Updated: Aug 03, 2020
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Patients with early-stage disease and unfavorable prognostic factors (eg, more than three sites of disease, bulky mediastinal disease, elevated erythrocyte sedimentation rate [ESR], extranodal extension) are classified as having early-stage unfavorable Hodgkin lymphoma. These individuals are treated differently than early-stage favorable patients. In general, four to six cycles of chemotherapy are given followed by involved-site radiation therapy (ISRT).

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