What is the role of radiation therapy in the treatment of early-stage, low risk Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The question as to whether radiation therapy is needed after combination chemotherapy in the treatment of early-stage disease is a matter of debate. When the largest trial to date (NCIC/Eastern Cooperative Oncology Group [ECOG] HD6 trial) examined ABVD alone versus ABVD followed by radiation in patients with early-stage Hodgkin lymphoma, the investigators reported that the chemotherapy alone arm had superior overall survival based on less late toxicity. [68] However, whether these results are applicable to patients treated on modern protocols with ISRT is unknown.


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