What are the treatment options for early-stage, low risk Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The treatment of these patients requires an individualized approach that provides enough therapy to eradicate the disease and avoid the long-term toxicity of treatment. Despite the existence of guidelines for the treatment, there must be room for individualized treatment, based on weighing of the benefits of therapy versus long-term toxicity.

In general, early-stage favorable Hodgkin lymphoma is treated with combined chemotherapy and radiation; however, there may be a role for chemotherapy alone. Randomized trials have shown that compared with radiation alone, combination chemotherapy followed by radiation is superior in terms of survival. [67]

The most commonly used regimen is ABVD (Adriamycin [doxorubicin], bleomycin, vinblastine, dacarbazine) for 2-4 cycles followed by involved-site radiation therapy (ISRT) (usually to 30 Gy). This regimen is the default regimen in the United States.


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