What are the commonly used salvage regimens for Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

When induction chemotherapy fails, or patients experience relapse, salvage chemotherapy is generally given. Salvage regimens incorporate drugs that are complementary to those that failed during induction therapy. Commonly used salvage regimens include the following:

  • ICE (ifosfamide, carboplatin, etoposide)
  • DHAP (cisplatin, cytarabine, prednisone)
  • ESHAP (etoposide, methylprednisolone, cytarabine, cisplatin)

Single-agent therapy is given as follows:

  • Brentuximab vedotin, 1.8 mg/kg once every 3 weeks for up to 16 cycles
  • Nivolumab, 3 mg/kg once every 2 weeks until disease progression or unacceptable toxicity
  • Pembrolizumab, 200 mg every 3 weeks until disease progression or excessive adverse effects, for a maximum of 24 months

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