What are possible long-term toxicities of Hodgkin lymphoma (Hodgkin disease) treatment?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Long-term toxicities vary based on patient age and treatment regimen. In general, the older the patient, the less the concern for long-term toxicity. Long-term toxicities and monitoring are described in detail later, but include the following:

  • Hematologic: Development of treatment-related myelodyplasia or acute leukemia

  • Pulmonary: Increased risk of lung cancer or fibrotic lung disease, particularly in smokers

  • Cardiac: Congestive heart failure from treatment, increased risk of coronary artery disease

  • Infectious: Long-term increased risk of infection from splenectomy (rarely done in current practice), long-term immunodeficiency from treatment effects

  • Cancer: Increased risk of secondary cancers, particularly breast cancer in young women treated with mediastinal radiation; increased risk of sarcomas in radiation fields; increased risk of lung cancer in smokers

  • Neurologic: Chemotherapy-induced neuropathy, muscular atrophy

  • Psychiatric: Depression and anxiety related to diagnosis and complications from treatment

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