What is the role of PET scanning in the staging of Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print

PET scanning is now considered essential to the initial staging of Hodgkin lymphoma, because of its ability to distinguish between viable tumor and necrosis or fibrosis in residual masses that are often present after treatment in patients who have no other clinical or biochemical evidence of disease. [36] This imaging study is often performed in conjunction with CT scanning (see the images below). [37] A mediastinal mass, representing mediastinal lymphadenopathy, is a very common finding in classical Hodgkin lymphoma, although it is uncommon in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL).

The American College of Radiology does not recommend changing chemotherapy or omitting radiation therapy based on PET scan response for early-stage patients. [29, 30]

A positron emission tomography (PET) scan obtained A positron emission tomography (PET) scan obtained with fluorodeoxyglucose (FDG) that shows increased FDG uptake in a mediastinal lymph node.
This image depicts a computed tomography (CT) scan This image depicts a computed tomography (CT) scan, positron-emission tomography (PET) scan, and maximum intensity projection (MIP) PET scan from a patient with histologically proven Hodgkin lymphoma.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!