How is Hodgkin lymphoma (Hodgkin disease) differentiated from hemophagocytic syndrome?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Occasionally, Hodgkin lymphoma can present as hemophagocytic syndrome (hemophagocytic lymphohistiocytosis). [35] The hemophagocytic syndrome may be more prevalent in patients with Epstein-Barr virus (EBV) antigen expression and has the following characteristics:

  • Pancytopenia

  • Fever

  • Hepatosplenomegaly with liver function test abnormalities

  • Elevated serum levels of ferritin and triglycerides

  • Phagocytosis of hematopoietic lineage cells by benign macrophages

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