What are the possible toxicities from treatment of Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Toxicities associated with treatment regimens include the following:

  • Hematologic toxicity: Anemia (need for transfusion), thrombocytopenia, increased risk of infection (febrile neutropenia); myelodyplasia or acute leukemia

  • Pulmonary toxicity, particularly if bleomycin or thoracic radiation are used; increased risk of lung cancer or fibrotic lung disease, particularly in smokers

  • Cardiac toxicity from anthracycline therapy; congestive heart failure from treatment; increased risk of coronary artery disease

  • Infectious: Long-term increased risk of infection from splenectomy (rarely done in current practice), long-term immunodeficiency from treatment effects

  • Cancer: Increased risk of secondary cancers, particularly breast cancer in young women treated with mediastinal radiation; increased risk of sarcomas in radiation fields

  • Neurologic: Chemotherapy-induced neuropathy, muscular atrophy

  • Psychiatric: Depression and anxiety related to diagnosis and complications from treatment

See Treatment and Medication for more detail.


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