What are the signs and symptoms of Hodgkin lymphoma (Hodgkin disease)?

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Features of Hodgkin lymphoma include the following:

  • Asymptomatic lymphadenopathy

  • Unexplained weight loss, unexplained fever, night sweats

  • Chest pain, cough, shortness of breath

  • Pruritus

  • Pain at sites of nodal disease

  • Back or bone pain

  • Nodular sclerosis Hodgkin lymphoma (NSHL) has a strong genetic component and has often previously been diagnosed in the family

  • Palpable, painless lymphadenopathy in the cervical area, axilla, or inguinal area

  • Involvement of the Waldeyer ring (back of the throat, including the tonsils) or occipital (lower rear of the head) or epitrochlear (inside the upper arm near the elbow) area

  • Splenomegaly and/or hepatomegaly

  • Superior vena cava syndrome may develop in patients with massive mediastinal lymphadenopathy

  • Central nervous system symptoms or signs may be due to paraneoplastic syndromes, including cerebellar degeneration, neuropathy, Guillain-Barre syndrome or multifocal leukoencephalopathy

See Presentation for more detail.

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