What are the therapeutic regimens for coagulase-negative staphylococci (CoNS) septic arthritis of prosthetic joints?

Updated: Oct 01, 2020
  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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See the list below:

  • Vancomycin 15 mg/kg IV q12h or

  • Linezolid 600 mg IV q12h or

  • Daptomycin 4-6 mg/kg IV q24h

  • Rifampin 300-450 mg PO/IV q12h; must be given if prosthetic material is present

  • In patients in whom it is difficult to maintain adequate trough levels of vancomycin (15-20 mcg/mL), consideration should be given to the use of linezolid or daptomycin [11]

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