How is hemolytic-uremic syndrome (HUS) treated?

Updated: Nov 30, 2019
  • Author: Perumal Thiagarajan, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Therapy for HUS is directed toward the underlying process. Acute and chronic renal failure is managed with fluid and electrolytes and, if necessary, dialysis. Plasma exchange therapy is often administered, but whether this is beneficial remains unclear. Antiplatelet and anticoagulant therapies have been attempted but do not show a marked benefit.

A role for the complement system in the pathogenesis of HUS is elucidated, and eculizumab, a monoclonal antibody that inhibits the formation of a cell membrane attack complex, is being studied.

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