What is the role of thrombopoietin receptor agonists in the treatment of chronic immune thrombocytopenic purpura (ITP) platelet disorder in adults?

Updated: Aug 05, 2017
  • Author: Perumal Thiagarajan, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Answer

In a significant proportion of patients with ITP, ineffective platelet production from megakaryocytes plays a major role in causing thrombocytopenia. Stimulation of megakaryopoiesis by exogenous agents improves the platelet count. Two thrombopoietin receptor agonists have been approved for the treatment of chronic refractory ITP: eltrombopag and romiplostim.


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