How is chronic immune thrombocytopenic purpura (ITP) platelet disorder in children treated?

Updated: Aug 05, 2017
  • Author: Perumal Thiagarajan, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Approximately 25% of children with ITP do not undergo spontaneous remission within 6 months and have a chronic course with remissions and relapse similar to adult-onset chronic ITP. The rate of chronic ITP appears to increase with advancing age, rising from 23.1% in children younger than 12 months to 47.3% in children older than 10 years, in one study. [18]

In a retrospective study of 47 children with chronic ITP who were not receiving corticosteroid therapy, 21 (44.7%) showed spontaneous remission according to new International Working Group standards, maintaining a platelet count of at least 100×109/L approximately 3-4 years following their diagnosis; 31 children (66%) maintained a platelet count of 50×109/L or higher through 5.4 years of follow-up. Lower age at diagnosis and longer follow-up were significantly associated with a better prognosis. [19]


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