What are the guidelines on measles, mumps, and rubella (MMR) vaccination in children with acute immune thrombocytopenia (ITP)?

Updated: Nov 30, 2019
  • Author: Perumal Thiagarajan, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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ITP may develop in children after measles, mumps, and rubella (MMR) vaccination. However, such cases occur at a lower rate than after natural measles or rubella infection, and recurrence of ITP has not been reported after MMR vaccination of unimmunized patients with ITP or re-vaccination of patients with previous nonvaccine- or vaccine-associated ITP. [16]

American Society of Hematology guidelines therefore recommend that unimmunized children with a history of ITP receive their first MMR vaccine on schedule. In a child with ITP who has already received the first dose of MMR vaccine and whose titers demonstrate full immunity, no further MMR vaccine should be given. If the child does not have adequate immunity, however, MMR vaccination should continue according to the recommended schedule. [16]

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