What causes platelet thromboxane synthesis disorders?

Updated: Nov 30, 2019
  • Author: Perumal Thiagarajan, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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During primary hemostasis, thromboxane synthesis and released ADP play a major role. A mild bleeding diathesis ensues if these mechanisms are deficient. Thromboxane synthesis disorders are almost always caused by aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).

Because aspirin irreversibly inactivates cyclooxygenase in platelets, its effect lasts throughout the life span of platelets, which is approximately 1 week. Approximately 10% of new nonaspirinized platelets are produced daily; after 3 days have elapsed since the discontinuation of aspirin (30% nonaspirinized platelets available), the bleeding time normalizes.

Other NSAIDs are competitive inhibitors of cyclooxygenase, and their effect on platelets depends on the half-life of the drug. For example, the effect of ibuprofen, and most other NSAIDs, lasts only 1 day.

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