Which common drugs are associated with thrombocytopenia?

Answer

Common drugs associated with thrombocytopenia include the following:

Amiodarone
Captopril
Sulfonamides
Glyburide (glibenclamide)
Carbamazepine
Ibuprofen
Cimetidine
Tamoxifen
Ranitidine
Phenytoin
Vancomycin
Piperacillin

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Media Gallery

Normal hemostasis.
Purpuric spots.
Spurious thrombocytopenia. Peripheral smear of a patient reported to have platelet counts of 10,000-150,000/μL on various occasions. The smear shows clumping of the platelets and satellitism involving neutrophils and platelets.
Examination of peripheral smears in immune thrombocytopenia often shows giant platelets. These platelets reflect the increased megakaryocytic mass in the marrow.
Peripheral smear of a patient with Bernard-Soulier syndrome showing giant platelets. These platelets are not counted as platelets in most particle counters.
Examination of the peripheral smear shows red blood cell fragments, basophilic cells, in addition to thrombocytopenia in thrombotic thrombocytopenic purpura.
Bone marrow in immune thrombocytopenia. Bone marrow examination reveals an increased number of megakaryocytes.
Vasculitis in childhood.
Schistocytes (thrombotic thrombocytopenic purpura).

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Author

Perumal Thiagarajan, MD Professor, Department of Pathology and Medicine, Baylor College of Medicine; Director, Transfusion Medicine and Hematology Laboratory, Michael E DeBakey Veterans Affairs Medical Center

Perumal Thiagarajan, MD is a member of the following medical societies: American College of Physicians, American Heart Association, American Society for Biochemistry and Molecular Biology, American Society for Clinical Investigation, American Society of Hematology, Association of American Physicians, Royal College of Physicians

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Ronald A Sacher, MBBCh, FRCPC, DTM&H Professor of Internal Medicine and Pathology, Director, Hoxworth Blood Center, University of Cincinnati Academic Health Center

Ronald A Sacher, MBBCh, FRCPC, DTM&H is a member of the following medical societies: American Association for the Advancement of Science, American Association of Blood Banks, American Clinical and Climatological Association, American Society for Clinical Pathology, American Society of Hematology, College of American Pathologists, International Society of Blood Transfusion, International Society on Thrombosis and Haemostasis, Royal College of Physicians and Surgeons of Canada

Disclosure: Nothing to disclose.

Chief Editor

Srikanth Nagalla, MBBS, MS, FACP Associate Professor of Medicine, Division of Hematology and Oncology, UT Southwestern Medical Center

Srikanth Nagalla, MBBS, MS, FACP is a member of the following medical societies: American Society of Hematology, Association of Specialty Professors

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Alexion; Alnylam.

Additional Contributors

Karen Seiter, MD Professor, Department of Internal Medicine, Division of Oncology/Hematology, New York Medical College

Karen Seiter, MD is a member of the following medical societies: American Association for Cancer Research, American College of Physicians, American Society of Hematology

Disclosure: Received honoraria from Novartis for speaking and teaching; Received consulting fee from Novartis for speaking and teaching; Received honoraria from Celgene for speaking and teaching.

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