How do drugs cause thrombocytopenia platelet disorders?

Updated: Aug 05, 2017
  • Author: Perumal Thiagarajan, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Answer

Drugs can induce thrombocytopenia by a number of mechanisms. [10] For example, the cytotoxic drugs can inhibit platelet production in the bone marrow, as can thiazide diuretics, interferon, and alcohol.

More commonly, drug-induced thrombocytopenia results from the immunologic destruction of platelets. Drugs can induce antibodies to platelets, either acting as a hapten or as an innocent bystander. In addition, drugs such as gold salts and interferon can induce an ITP-like disorder.


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