What is the role of elevated inflammation in the development of suicide behaviors?

Updated: Sep 25, 2018
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Answer

O'Donovan A et al found that individuals with major depressive disorder (MDD) who attempt suicide or successfully achieve it have elevated inflammation compared with nonsuicidal patients. They also determined that patients with MDD and high suicidal ideation had significantly higher inflammatory index scores than controls. They used inflammatory index based on markers tumor necrosis factor-α, interleukin-6, interleukin-10, and C-reactive protein. They concluded inflammation is associated with suicidal ideation in patients with MDD. [107]


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