What are the organism-specific therapeutic regimens for Bordetella pertussis bronchitis?

Updated: Jul 22, 2021
  • Author: Jazeela Fayyaz, DO; Chief Editor: John J Oppenheimer, MD  more...
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Bordetella pertussis (incubation period of 1-3 weeks, fever is uncommon, suspect if cough persists for >2 weeks) [2] :

  • First-line treatment is macrolides:

    • Azithromycin 500 mg PO on day 1, then 250 mg PO q24h on days 2-5 or

    • Erythromycin 500 mg PO QID for 14 days or

    • Clarithromycin 500 mg PO BID for 7 days

  • Second-line treatment:

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