What are indications for outpatient and inpatient therapy in cellulitis empiric therapy?

Updated: Sep 13, 2018
  • Author: Alfred Scott Lea, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Answer

Outpatient therapy with oral antibiotics is indicated for healthy individuals who have no evidence of systemic inflammatory response syndrome (SIRS). [1]

Inpatient therapy with parenteral antibiotics is recommended for patients with associated SIRS, hemodynamic instability, and/or mental status changes. Poor compliance, failure to respond to oral antibiotics, facial involvement, and immune suppression are additional indications for inpatient parenteral therapy until the patient is stable and improving. The initial antibiotic selection should cover MRSA for patients with coexisting penetrating and/or surgical trauma, evidence of MRSA infection elsewhere, known nasal MRSA colonization, and intravenous drug abuse. Coverage should also take into consideration the prevalence of MRSA in the patient’s hospital and community. [1, 6]


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