What is the outpatient empiric therapy regimen for patients with community-acquired pneumonia (CAP) and comorbidities?

Updated: Jul 25, 2018
  • Author: Fariba M Donovan, MD, PhD; Chief Editor: Thomas E Herchline, MD  more...
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Answer

Answer

Levofloxacin 750 mg PO q24h or

Moxifloxacin

400 mg PO q24h

or

Combination of a beta-lactam (

amoxicillin

1 g PO q8h

or

amoxicillin-clavulanate

2 g PO q12h

or

ceftriaxone

1g IV/IM q24h

or

cefuroxime

500 mg PO BID)

plus

a macrolide (azithromycin

or

clarithromycin)

Duration of therapy: minimum of 5 days, should be afebrile for 48-72 hours, or until afebrile for 3 days; longer duration of therapy may be needed if initial therapy was not active against the identified pathogen or if it was complicated by extrapulmonary infections


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