When was hemolytic-uremic syndrome (HUS) first described?

Updated: Oct 25, 2019
  • Author: Malvinder S Parmar, MBBS, MS, FRCPC, FACP, FASN; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Gasser et al first described HUS in 1955. In 1988, Wardle described HUS and TTP as distinct entities, but in 1987, Remuzzi suggested that these two conditions are varied expressions of the same entity.

Confirmation that HUS and TTP are clearly different diseases, despite their clinical similarities, followed the discovery of the von Willebrand factor (vWF)–cleaving metalloprotease ADAMTS13 (A disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13). Researchers subsequently recognized the etiologic link between TTP and congenital deficiencies of ADAMTS13 or formation of acquired antibodies to ADAMTS13. [5, 6, 7, 8]

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