How is screening for sickle cell syndrome performed in the workup of hemolytic anemia?

Updated: May 27, 2021
  • Author: Srikanth Nagalla, MD, MS, FACP; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

Screening for sickle cell syndrome is performed by demonstrating sickling under reduced conditions (sickle cell preparations) and testing for hemoglobin solubility (see the image below). Hemoglobin electrophoresis confirms the presence of abnormal hemoglobin.

Peripheral blood smear with sickled cells at 1000X Peripheral blood smear with sickled cells at 1000X magnification. Image courtesy of Ulrich Woermann, MD.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!